Abstract SAMHD1 is a dNTPase that impedes replication of HIV-1 in myeloid cells and resting T lymphocytes.Here we elucidate the substrate activation mechanism of SAMHD1, which involves dNTP binding at allosteric sites and transient tetramerization.Our findings reveal that tetramerization alone is insufficient to promote dNTP hydrolysis; instead, th
The results of the development of the hardware and software complex for electromechanical equipment diagnostic by electrical power consumption parameters are presented.The connection of the prototype of the above-mentioned complex to the laboratory Elderberry / Sambucus stand for vibration diagnostics of electromechanical equipment and the obtained
ABSTRACTAs important as the establishment of projects of ecological restoration is its assessment post-implementation to know whether the area is becoming self-sustainable or need to be redirected.In this way, this study aimed to know the current situation of a 5-year-old rehabilitated riparian forest,inserted in an anthropogenic impacted region,at
Abstract Background Body mass index (BMI) has been shown to be associated with lung function.Recent findings showed that DNA methylation (DNAm) variation is likely to be a consequence of changes in BMI.However, whether DNAm mediates the association of BMI with lung function is unknown.We examined the mediating role of DNAm on the association of pre